Raylene Reimer De Bruyn
Professor, Associate Dean (Research)
PhD - Food & Nutritional Science
Research and teaching
Exercise Physiology & Nutrition in Health & Sport
The Reimer Research Group focuses on understanding the full potential of nutrition to prevent and treat obesity and type 2 diabetes. Their research spans basic science aimed at determining the mechanisms through which diet affects the progression and maintenance of obesity through to applied human clinical studies evaluating the effectiveness of novel dietary interventions.
They have made significant progress in understanding how maternal diet during pregnancy ‘programs’ the risk of obesity and impaired glucose tolerance in offspring. Altering the macronutrient composition of maternal diet, in this case the dietary protein and fiber content, led to permanent changes in the accumulation of body fat and the ability to handle oral glucose in the offspring. Further insight into the lasting influence that maternal health status has on long-term offspring health is being gained from work examining the aggressive treatment of obesity in female animals prior to becoming pregnant. The group is currently using metabolomics to examine the global metabolite profile of pregnant rats fed an obesogenic diet and a high fiber diet. Given the clear evidence that dietary environment experienced early in life has long-term consequences for health and disease risk, the goal in this work is to determine the most effective means of reducing programmed obesity risk in offspring.
The Reimer Research group is also making progress in understanding the link between the human host and intestinal microbial communities. Recent evidence suggests that the abundant and diverse communities of bacteria in the intestine influence energy metabolism and thereby affect the development of obesity. They examine the effect of modifying intestinal bacteria toward healthy profiles with prebiotics (unique dietary fibers that selectively fuel healthy gut bacteria) and probiotics (live bacteria that confer a health benefit to the host). They have ongoing work translating this animal work into human clinical trial examining the effects of a prebiotics on appetite, food intake, and weight loss in overweight adults.
The long-term goal of the work is to identify novel nutritional therapies to prevent and treat chronic disease.
Professor, Associate Dean (Research), Faculty of Kinesiology
Professor, Faculty of Medicine, Department of Biochemistry & Molecular Biology
College of Dietitians of Alberta
The Obesity Society
American Society for Nutritional Sciences
Canadian Nutrition Society
American Chemical Society
Current Grant Support
2014-2018 CIHR (Canadian Institutes of Health Research):Prebiotic fiber supplementation and gut microbiota in non-alcoholic fatty liver disease. Principal Investigator: $618,884.
2011-2016 CIHR (Canadian Institutes of Health Research) Operating Grant: Dietary manipulation of gut microbiota to manage obesity and insulin resistance. Principal Investigator: $568,565.
2016-2021 NSERC (Natural Sciences & Engineering Research Council) Discovery Grant (04/2016-03/2021) Mechanisms by which early life nutritional factors program postnatal metabolism. Principal Investigator: $280,000.
2013-2017 BMO Financial Group Endowed Research Fund in Healthy Living (2013-2016) Team development in pediatric obesity. Principal Investigator: $300,000.
Kristine Lee, Technician
Teja Klancic, PhD Student
Jodi Nettleton, PhD Student
Fatima Chleilat, PhD student
Nicole Cho, PhD student
Emily Macphail, MSc student
Shyamchand Mayengbam, Postdoctoral Fellow
Rafael Fortuna, Postdoctoral Fellow
Lindsay Eller, Research Associate
Participate in Research Studies
For a list of ongoing research studies and details around participation please consult the University of Calgary research participation website and enter Raylene De Bruyn into the search tab.
For a list of publications, please see CV above.