Wendie Marks

Postdoctoral Scholar

Faculty of Kinesiology

PhD

University of Saskatchewan

Contact information

Location

Heritage Medical Research Building : HMRB, 3330 Hospital Drive, NW Calgary. 291

Research and teaching

Research areas

  • Behavioural Neuroscience
  • Brain Disorders
  • Gut-brain Axis

Ketogenic diet and infantile spasms

Mark's postdoctoral work examines the effects a ketogenic diet on a triple-hit model of infantile spasms. Infantile spasms are a catastrophic, epileptic encephalopathy of infancy characterized by epileptic spasms, hypsarrhythmia, and often severe cognitive impairment. Infantile spasms are often refractory to current antiepileptic drugs. However, evidence from Dr. Scantlebury and Dr. Shearer’s lab suggests that a ketogenic diet in the triple-hit model of infantile spasms is effective at decreasing the severity of spasms. Mark's will focus on examining the long-term effects of the ketogenic diet on cognition in rat pups subjected to the triple-hit model of infantile spasms.


Biography

Supervisors: Drs. Jane Shearer and Morris Scantlebury. 


Publications

Marks, W.N., Zabder, N.K., Greba, Q., Cain, S.M., Snutch, T.P., & Howland, J.G. (2019). The T-type calcium channel blocker Z944 reduces conditioned fear in Genetic Absence Epilepsy Rats from Strasbourg and the Non-Epileptic Control strain. European Journal of Neuroscience. (In press)

Lins, B.R., Marks, W.N., Zabder, N.K., Greba, Q., & Howland, J.G. (2019). Maternal immune activation during pregnancy alters the behavior profile of female offspring in Sprague-Dawley rats. eNeuro. (In press)

Marks, W.N., Zabder, N.K., Cain, S.M., Snutch, T.P., & Howland, J.G. (2019). The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg. Behavioural Brain Research, 361, 54-64.

Paylor, J.W., Wendlandt, E., Freeman, T.S., Greba, Q., Marks, W.N., Howland, J.G., & Winship, I.R. (2018). Impaired cognitive function after perineuronal net degradation in the medial prefrontal cortex. eNeuro, 5, 1-15.

Roebuck, A.J., Marks, W.N., Liu, M.C., Tahir, N.B., Zabder, N.K., Snutch, T.P., & Howland, J.G. (2018). Effects of the T-type calcium channel antagonist Z944 on paired associates learning and locomotor activity in rats treated with the NMDA receptor antagonist MK-801. Psychopharmacology, 235, 3339-3350.

Lins, B.R., Hurtubise, J.L., Roebuck, A.J., Marks, W.N., Zabder, N.K., Scott, G.A., Greba, Q., Dawicki, W., Zhang, X., Rudulier, C.D., Gordon, J.R., & Howland, J.G. (2018). Prospective analysis of the effects of maternal immune activation on rat cytokines during pregnancy and behavior of the male offspring relevant to schizophrenia. eNeuro, 5, 1-18.

Marks, W.N., Parker, M.E., Zabder, N.K., Snutch, T.P., & Howland, J.G. (2018). T-type calcium channels in the orbitofrontal cortex mediate uni- and multisensory integration. Learning & Memory, 25, 317-324.

Marks, W.N., & Kalynchuk, L.E. (2017). Repeated corticosterone enhances acquisition and recall of trace fear conditioning. Physiology & Behavior, 182, 40-45.

Henbid, M.T.1, Marks, W.N.1, Collins, M.J., Cain, S.M., Snutch, T.P., & Howland, J.G. (2017). Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: reversal by the T-type calcium channel antagonist Z944. Experimental Neurology, 296, 16-22. 1co-first author.

Lins, B.R1., Marks, W.N.1, Phillips, A.G., & Howland, J.G. (2017). Dissociable effects of the d-and l-enantiomers of govadine on the disruption of prepulse inhibition by MK-801 and apomorphine in male Long Evans rats. Psychopharmacology, 234, 1079-1091. 1co-first author.

Hurtubise, J.L., Marks, W.N., Davies, D.A., Catton, J.K., Baker, G.B., & Howland, J.G. (2017). MK-801 induced impairments on the Trial-Unique, Delayed Nonmatching-to-Location task in rats: effects of acute sodium nitroprusside. Psychopharmacology, 234, 211-222.

Marks, W.N., Greba, Q., Cain, S.M., Snutch, T.P., & Howland, J.G. (2016). The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. Neuroscience, 332, 121-129.

Marks, W.N., Cain, S.M., Snutch, T.P., & Howland, J.G. (2016). The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiology of Disease, 94, 106-115.

Marks, W.N., Cavanagh, M.E., Greba, Q., Cain, S.M., Snutch, T.P., & Howland, J.G. (2016). The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans. European Journal of Neuroscience, 43, 25-40.

Marks, W.N., Fenton, E.F., Guskjolen, A.J., & Kalynchuk, L.E. (2015). The effect of chronic corticosterone on fear learning and memory depends on dose and the testing protocol. Neuroscience, 289, 324-333.

Botterill, J.J., Guskjolen, A.J., Marks, W.N., Caruncho, H.J., & Kalynchuk, L.E. (2015). Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor. Brain Structure and Function, 220, 3641-3655.

Botterill, J.J., Fournier, N.M., Guskjolen, A.J., Lussier, A.L., Marks. W.N., & Kalynchuk, L.E. (2014). Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain. Neuroscience, 265, 158-71.

Fournier, N.M., Botterill, J.J., Marks, W.N., Guskjolen, A.J., & Kalynchuk, L.E. (2013). Impaired recruitment of seizure-generated neurons into functional memory networks of the adult dentate gyrus following long-term amygdala kindling. Experimental Neurology, 244, 96-104.

Marks, W., Fournier, N.M., & Kalynchuk, L.E. (2009). Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. Physiology and Behavior, 98, 67-72.


Awards

2018 - Canadian Spring Conference on Behaviour and Brain (Second Place) Postdoctoral Fellow Presentation) - $70

2017 - Canadian Association for Neuroscience Advocacy Travel Award - $500               

2016 - Neuroscience Research Retreat (First Place Platform Presentation) - $100 

2016 - SHRF Fellowship - $100,000 over 2 years  

2015 - Postdoctoral Fellowship Bridge Funding - $40,000    

2013 - Graduate Student Association Bursary Award - $1,000

2012 - SIGA First Nation Scholarship - $2,500 

2012 - First Nation, Inuit & Metis Post-Secondary Education Bursary Award - $2,400   

2012 - Canadian Federation of University Women Saskatoon Inc. Newstead Doctoral Scholarship - $5,000

2011 - SIGA First Nation Scholarship - $1,000 

2011 - First Nation, Inuit & Metis Post-Secondary Education Bursary Award - $2,100 

2011 - Moose Meat Apparel Bursary - $250                                                                                     

2010 - College of Graduate Studies and Research Travel Award - $550                                     

2010 - Queen Elizabeth II Centennial Aboriginal Scholarship - $20,000                           

2010 - Orange Benevolent Society Scholarship - $2,000 

2009 - NSERC Doctoral Postgraduate Scholarship - $42,000 over 2 years

2009 - Orange Benevolent Society Scholarship - $2,500                     

2008 - University of Saskatchewan Graduate Teaching Fellowship - $16,000

2005 - NSERC Master’s Postgraduate Scholarship - $34,600 over 2 years   

2002 - Dean’s Honour List              

2002 - University of Saskatchewan Undergraduate Scholarship - $1,500    

2002 - Chase Memorial Scholarship - $1,900  

2001 - Coca-Cola Entrance Scholarship - $3,500 

2000 - University of Regina Scholar - $11,200 over 4 years (declined award)   

2000 - Saskatchewan General Proficiency Award - $400               

2000 - Bedford Road Collegiate Institute Proficiency Award - $500  

2000 - Dr. J.R. McKay Award - $50   

2000 - The Governor General’s Academic Medal (Bronze)