March 15, 2018

UCalgary researchers develop portable brain imaging system that could shed light on concussions

Technology to be used in study at Alberta Children’s Hospital to monitor injury and recovery timelines

Author

Kelly Johnston, Cumming School of Medicine

University of Calgary researchers have developed a brain imaging system that may one day be used in concussion treatment clinics and sports facilities to detect and monitor damage in the brain from concussion. From left, Ibukunoluwa Oni, graduate student with the Experimental Imaging Centre; Carter Randall, undergraduate research assistant; and Jeff Dunn, PhD, director of the Experiment Imaging Centre at the Cumming School of Medicine. Photos by Pauline Zulueta, Cumming School of Medicine

From left: Ibukunoluwa Oni, graduate student; Carter Randall, research assistant; and Jeff Dunn.

Pauline Zulueta, Cumming School of Medicine

It’s one of the most talked about injuries in sport today: concussion. Yet there is no accepted way to image a concussion. University of Calgary scientist Jeff Dunn, PhD, hopes to change that. He and his team have developed a portable brain imaging system that uses light to detect and monitor damage in the brain from concussion. Researchers and doctors will be using the technology in an upcoming study at the Alberta Children’s Hospital.  

The device, a Near-Infrared Spectroscopy (fNIRS), measures communication in the brain by measuring oxygen levels. When the brain is working well, major regions on each side of the brain are communicating and so have similar patterns of blood flow and oxygen levels in blood. Researchers measure the changes in blood oxygen levels as a marker of brain function. Results show these patterns change after concussion.

“The one thing we know is that there can be physiological changes in the brain that last for months to years after a brain injury due to concussion. We discovered a new technology that is portable to measure those changes,” says Dunn, director of the Experimental Imaging Centre at the Cumming School of Medicine (CSM). “We will now apply this new technology to see how important these changes are, as we try to understand how concussion evolves over time.”

Dunn became interested in finding a way to image concussion after his children became involved in ski racing.

“A lot of kids on the ski hill were getting head hits and it was really very apparent that there wasn’t an imaging method that could help them,” says Dunn, who is also a member of the Hotchkiss Brain Institute and Alberta Children’s Hospital Research Institute at the CSM. “Currently, concussion is often measured by the symptoms someone experiences, but we really don’t know what’s happening in the brain in any one person.”

Symptoms can vary greatly between individuals, and can include headaches, nausea, loss of memory and lack of co-ordination (to name a few), making it even more difficult to find treatment options for each person. Through his research, Dunn hopes the images will show a connection between symptoms and abnormalities in the brain that could help doctors identify treatment protocols and recovery timelines.

In partnership with Alberta Health Services and with the support of the Canadian Institutes of Health Research, Dunn will be teaming up with physicians at the Alberta Children’s Hospital, and other UCalgary researchers at the CSM and in the faculties of kinesiology and arts to use the imaging device to study concussion in children.

“We will be able to follow young patients over time to establish whether this new technology can help us determine the extent of the injury and how the brain is recovering,” says Dunn.

Ibukunoluwa Oni places the brain imaging cap, which contains LED lights that illuminate the skull and allow researchers to monitor and measure brain activity.

Ibukunoluwa Oni places the brain imaging cap, used to monitor and measure brain activity.

Pauline Zulueta, Cumming School of Medicine

Keith Yeates, PhD, lead for the university’s Integrated Concussion Research Program and a co-investigator on the study, says the technology has important practical benefits. “The fNIRS device has the potential to provide a convenient method for helping detect concussion.”

To image the brain, the researchers place a cap, similar to a swim or bathing cap, on the top of the head. The cap contains small lights that have sensors connected to a computer. When researchers turn on the lights, they can monitor and measure brain activity. The device is non-invasive and portable.

While most often associated with sports, concussion affects thousands of Canadians a year who experience a fall or a car accident. While most people recover, some experience long-term effects and disabilities. 

A recent study, by Dunn and colleagues, showed promising results of the device’s ability to detect changes in brain activity in adults with long-term symptoms post-concussion. The findings are published in the Journal of Neurotrauma. This research is still ongoing at the Foothills Medical Centre.

If this new technology proves to be an effective tool for monitoring injury and recovery timelines Dunn hopes, one day, to see the technology widely used in concussion treatment clinics and sports facilities.

 

Led by the Hotchkiss Brain Institute, Brain and Mental Health is one of six research strategies guiding the University of Calgary toward its Eyes High goals. The strategy provides a unifying direction for brain and mental health research at the university and positions researchers to unlock new discoveries and treatments for brain health in our community. 

The University of Calgary’s multidisciplinary Engineering Solutions for Health: Biomedical Engineering research strategy drives solutions to our most pressing health challenges in disease and injury prevention, diagnosis and treatments. Our biomedical engineering researchers make a significant impact in our communities by extending lives, improving quality of life, promoting independence, and continuously improving the health system.

The Hotchkiss Brain Institute and the Alberta Children’s Hospital Research Institute are both partnerships between the University of Calgary and Alberta Health Services.

The Dunn lab has also received support from the Natural Sciences and Engineering Research Council of Canada, the Integrated Concussion Research Program and the Alberta Children’s Hospital Foundation.

Jeff Dunn is a professor in the Department of Radiology, and an adjunct professor in the departments of clinical neurosciencesphysiology and pharmacology and is a member of the Hotchkiss Brain Institute and the Alberta Children’s Hospital Research Institute at the Cumming School of Medicine.

Keith Yeates, PhD, is a professor in the Department of Psychology in the Faculty of Arts and an adjunct professor in the departments of clinical neurosciences and paediatrics at the CSM. Yeates is the Ronald and Irene Ward Chair in Pediatric Brain Injury and is a member of the Hotchkiss Brain Institute, the Alberta Children’s Hospital Research Institute and the Owerko Centre at the CSM.